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BioCleanseTM

Herbal Laxative

$62.47


100 Capsules     Herbal Digestion Formula

  • Natural herbal laxative*
  • Supports healthy digestive system*
  • Detoxifying remedy for various other ailments*
  • Tab 1

     

    • Used as a herbal laxative for people with constipation
    • Removes waste from the bowels and cleanses the colon
    • Improves muscle tone of the colon walls
    • Supports healthy digestive functioning
    • Complimentary treatment  when suffering from hemorrhoids, gallstones, and liver ailments
    • Can be used for detoxification and some weight loss diets. 

    Biogenique IntraCleanse contains herbs from natural sources with high medicinal properties. As it is a fully natural formula, it produces less habituation and fewer side effects whilst carrying out digestive duties, and can therefore be used for longer periods of time. Biogenique IntraCleanse is a pharmaceutical grade, innovative formula designed to help you make the right impact on your digestive system and overall health. 

    Why Biogenique?


    The application of Structurally Active-Orthogenic (SAO) technology by Biogenique’s research and production team ensures that all available products are of a heightened quality. 

    SAO technology produces active ingredients with strong molecular composition and the highest bioavailability (ratio of inactive/active ingredients) in order to ensure synergistic applications occur within the body. In other words, the Biogenique label ensures that all our products are able to be optimally absorbed by the bloodstream at the molecular level, and don’t just pass through the body undigested. 

    Biogenique is pharmaceutically tested and clinically verified by careful examination at every stage of production. The protocols are measured and confirmed for international standard compliance before the product is introduced to market. 

    Biogenique only uses 100% natural ingredients. 




    Tab 1

    Active Ingredients


    Cascara Sagrada (Frangula Purchiana, Aged Bark)………………….….……150mg
    Senna Leaves (Senna Alexandrina, Leaf)……………………………………....100mg
    Aloe Vera Leaves…………………………………………………………………..50mg
    Cayenne (Capsicum Annum, Fruit)……………………………………………...10mg
    Dandelion Root Powder (Taraxcum Officinale, Root)……………………….....25mg 

     

    Tab 3

    BioCleanseTM

     

    NPN:

     

    80035902 

     

    Quantity:


    100 Veggie Capsules

     

     

    Non Medicinal Ingredients:

     

    Fennel seed, alfalfa herb, parsley leaf, vegetable magnesium stearate, rice flour, vegetable, silicon dioxide.

     

    This Product Does Not Contain:


    Gelatin, sugar, dairy or preservatives. 

    Recommended Use:


    Traditionally used in herbal medicine as a stimulant laxative and to aid digestion. 

    Recommended Dose:


    Adults and adolescents: (12 years and over) Take 2-4 capsules 1 time per day. Take 2-3 times per week. if results are not observed, the frequency of use may be increased up to once daily. Take a few hours before or after taking other medications or health products. Allow at least 6 to 12 hours for laxative effect to occur. 

    Risk Information:

     

    Cautions & Warnings:


    Consult a healthcare practitioner if symptoms persist or worsen, if you have stomach ulcers or inflammation, fecal impaction or symptoms such as abdominal pain, nausea, vomiting or fever, kidney disorders or if you are taking cardiac medications such as cardiac glycosides or antiarrhythmic medications, or taking thiazide diuretics, corticosteroids, licorice root or other medications or health products which may aggravate electrolyte imbalance. 

    keep out of reach of children.

     

    Contraindications:


    Do not use in the following cases: If you are pregnant or breastfeeding. If you have abdominal constrictions of the gastrointestinal tract, potential or existing intestinal blockage, atonic bowel, appendicitis, inflammatory colon disease such as Crohn's disease or ulcerative colitis, abdominal pain of unknown origin, undiagnosed rectal bleeding, severe dehydration with deplete water or electrolytes or diarrhea.

    Storage:


    • Seal for tamper resistant protection.
    • If Seal is broken do not use.
    • Store at room temperature 15-30 C
    • Protect from Moisture 

    download monograph

     





    Tab 3

    Tab 3 Content

    Tab 1

    Background


    Biogenique IntraCleanse is herbal supplement from natural and pure sources. The active ingredients include Cascara sagrada, Senna leaves, Aloe vera leaves, Cayenne (capsicum) and Dandelion roots. The dried, aged bark of Cascara has been used continually for many years by both Pacific Northwest native peoples and immigrant Euro-Americans as a laxative natural medicine, as one of several anthraquinone-containing herbal medicines including the leaf and fruits of senna, the latex of Aloe vera, and the root of the rhubarb plant.

    Biogenique Structurally Active-Orthogenic (SAO) technology


    At Biogenique, the Cascara’s bark is aged for a year and undergoes series of special heat treatment before being used. Our SAO technology breaks down the anthrone chemicals in Cascara sagrada so that the active principle become milder, making the formulation least irritating and most suitable as laxative. Freshly dried bark should not be used, because it can cause intestinal spasms, vomiting, bloody diarrhea and produces too strong a laxative for safe use. 
    SAO technology establishes a higher caliber of science for better quality research and formulation. It makes sure that the compounds are delivered on their potential by careful examination at every stage—formulation, ingredient selection, quality assays, manufacture, dissolution, taste, and tolerance. The protocols are refined, measured for compliance, and confirmed for effectiveness before the product is introduced to market. 

    SAO Analysis


    Cascara Sagrada
    Cascara contains active compound - anthraquinones that trigger contractions in the colon, called peristalsis, which causes the urge to have a bowel movement. Today, it is one of the most common herbal laxatives. 

    Senna leaves
    Senna contains active compounds called sennosides. Sennosides irritate the lining of the bowel, which causes a laxative effect. Senna relieves constipation by stimulating the muscles of the colon to push fecal matter through more quickly. It may also help your colon absorb water to soften stool. You may expect a bowel movement within six to 10 hours of taking senna, according to the National Cancer Society. Senna is widely accepted as a stool softener and a short-term treatment for constipation. Senna leaf is approved by the World Health Organization (WHO) for short-term use in occasional constipation. 

    Dandelion roots
    Dandelion contains actives that increase urine production and decrease swelling (inflammation). It is also used as a laxative to increase bowel movements, as skin toner, blood tonic, and digestive tonic. 

    Aloe Vera 
    The useful parts of aloe are the gel and latex. Biogenique SAO technology uses aloe latex. Aloe latex comes from just under the plant's skin and is yellow in color. It is obtained from the cells just beneath the leaf skin. Aloe latex contains actives that work as a laxative and seems to be able to speed wound healing by improving blood circulation through the area and preventing cell death around a wound. 

    Scientific Evidence


    Bowel cleansing

    Early studies have examined the use of cascara for bowel preparation. 

    Constipation

    Cascara sagrada is widely accepted as a mild and effective treatment for chronic constipation. Cascara shouldn’t be used for more than one to two weeks without medical supervision due to risk of hypokalemia (Potassium loss). Clinical studies in the United States and abroad involving various age groups suggest that senna is effective in managing constipation associated with a number of causes including surgery, childbirth, and use of narcotic pain relievers. A study in the medical journal Diseases of the Colon and Rectum showed that senna was able to prevent or treat postoperative constipation after proctologic surgery. The South African Medical Journal shows that treatment with senna was successful in 93%-96% of women suffering from postpartum constipation. By comparison, only 51%-59% of women in the placebo group experienced relief. Senna and other stimulant laxatives should not be used for longer than two to four weeks without medical supervision. Using senna longer than recommended can result in lazy bowel syndrome and permanent damage to the intestinal lining. 

    Clinical Trials


    • Influence of senna, fibre, and fibre + senna on colonic transit in lope amide-induced constipation: All of the three study drugs increased stool weight significantly (p < 0.05). aWhen stool frequency and consistency were compared, the effects were less clear. Pharmacology. 1993 Oct;47 Suppl 1:242-8; Ewe K, Ueberschaer B, Press AG; I. Medizinische Klinik und Poliklinik, Johannes-Gutenberg-Universität Mainz, FRG

    • Clinical observation on treatment of functional constipation with compound plantain-senna granules: Compound plantain-senna granules can obviously increase the defecating frequency, change the stool property, alleviate the fecal discharging difficult symptom and accompanied symptom, and shorten the gastrointestinal transmission time in patients with functional constipation with good security and tolerability. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009 Dec;29(12):1119-22; Zhang CX; Department of Digestive Medicine, the First Affiliated Hospital of Xinxiang Medical College, Henan Weihui

    • The use of senna with docusate for postoperative constipation after pelvic reconstructive surgery: a randomized, double-blind, placebo-controlled trial: The use of senna with docusate decreases time to first bowel movement in those undergoing pelvic reconstructive surgery compared with placebo. Subjects using senna with docusate are also significantly less likely to use magnesium citrate. Am J Obstet Gynecol. 2010 May;202(5):479.e1-5. Epub 2010 Mar 6; Patel M, Schimpf MO, O'Sullivan DM, LaSala CA; Division of Urogynecology, Department of Obstetrics and Gynecology, University of Connecticut School of Medicine, Hartford Hospital, Hartford, CT 06106, USA 

    Safety


    Biogenique IntraCleanse is LIKELY SAFE for most adults when used moderately. Don’t give IntraCleanse to children. They are more likely than adults to become dehydrated and also harmed by the loss of electrolytes, especially potassium. Pregnancy and breast-feeding: Not enough is known about the use of IntraCleanse during pregnancy. Stay on the safe side and avoid use if you are pregnant. It is POSSIBLY UNSAFE during breast-feeding. Cascara can cross into breast milk and might cause diarrhea in a nursing infant. Gastrointestinal (GI) disorders such as intestinal obstruction, Crohn’s disease, ulcerative colitis, appendicitis, stomach ulcers, or unexplained stomach pain: People with any of these conditions should not use IntraCleanse. 

    Interactions You Should Know About


    • Digoxin (Lanoxin) interacts with CASCARA Cascara is a type of laxative called a stimulant laxative. Stimulant laxatives can decrease potassium levels in the body. Low potassium levels can increase the risk of side effects of digoxin (Lanoxin). 

    • Medications for inflammation (Corticosteroids) interacts with CASCARA Some medications for inflammation can decrease potassium in the body. Cascara is a type of laxative that might also decrease potassium in the body. Taking cascara along with some medications for inflammation might decrease potassium in the body too much. 

    Some medications for inflammation include dexamethasone (Decadron), hydrocortisone (Cortef), methylprednisolone (Medrol), prednisone (Deltasone), and others. • Medications taken by mouth (Oral drugs) interacts with CASCARA Cascara is a laxative. Laxatives can decrease how much medicine your body absorbs. Decreasing how much medicine your body absorbs can decrease the effectiveness of your medication. 

    • Warfarin (Coumadin) interacts with CASCARA Cascara can work as a laxative. In some people cascara can cause diarrhea. Diarrhea can increase the effects of warfarin and increase the risk of bleeding. If you take warfarin do not to take excessive amounts of cascara. 

    • Water pills (Diuretic drugs) interacts with CASCARA Cascara is a laxative. Some laxatives can decrease potassium in the body. "Water pills" can also decrease potassium in the body. Taking cascara along with "water pills" might decrease potassium in the body too much. 

    Some "water pills" that can decrease potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril, Microzide), and others. 

    Selected references


    1. Stargrove, M.B. et al., ed. (2008). Herb, Nutrient, and Drug Interactions: Clinical Implications and Therapeutic Strategies. Elsevier Health Sciences. p. 17. ISBN 9780323029643. 

    2. Duke, James A., Michael Castleman, and Alice Feinstein. The Green Pharmacy. Emmaus, PA: Rodale Press, 1997.

    3. Foster, Steven and Varro E. Tyler. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. Binghamton, NY: Haworth, 1998.

    4. Goldberg, Burton. Alternative Medicine: The Definitive Guide. Fife, WA: Future Medicine Publishing, 1993.

    5. Agra, Y. Sacristan and M.A. Gonzalez. "Efficiency of Senna versus Lactulose in Terminal Cancer Patients Treated with Opioids." Journal of Pain and Symptom Management (1998) 15(1): 1-7.

    6. Corman, M.L. "Management of Postoperative Constipation in Anorectal Surgery." Diseases of the Colon and Rectum (1979) 22(3): 149-51.

    7. "Go for Natural Laxative Relief, but Best if not from Senna or Cascara." Environmental Nutrition (May 2002).

    8. Shelton, M.G. "Standardized Senna in the Management of Constipation in the Puerperium: A Clinical Trial." South African Medical Journal (1980) 57(3): 78-80.

    9. American Botanical Council. P.O. Box 144345, Austin, TX 78714-4345. (512) 926-4900. http://www.herbalgram.org.

    10. Herb Research Foundation.1007 Pearl Street, Suite 200, Boulder, CO 80302. (303) 449-2265. Info@herbs.org. http://www.herbs.org.

    11. Prevention Magazine. http://www.prevention.com. 

     




    Tab 3

    I)Bowel preparation prior to colonoscopy: a continual search for excellence.


    Source

    Division of Gastroenterology, University of Missouri, Columbia, MO 65201, United States. bechtoldm@health.missouri.edu 

    ABSTRACT

    Bowel preparation prior to colonoscopy is essential to maximize the benefits of colonoscopy. Numerous bowel preparations have been studied, ranging from 4 L polyethylene glycol (PEG) to split-dose regimens to 2 L PEG with an adjunct laxative (senna, bisacodyl, ascorbic acid). Due to the large volume of PEG required for adequate bowel preparation, many studies have focused on reducing this large volume to only 2 L PEG with the addition of an adjunct. Recently, a randomized controlled trial by Tajika et al showed that the addition of mosapride to only 1.5 L PEG was non-inferior to mosapride and 2 L PEG for bowel cleansing but did provide improvements in patient tolerance. This study offers yet another potential bowel preparation for patients undergoing colonoscopy and may trigger further studies with 1.5 L PEG with an adjunct. In this letter, we discuss the current state of bowel preparation prior to colonoscopy and offer information to guide clinicians on choosing the appropriate bowel preparation for their patients. 

    II)A double-blind trial of a celandin, aloevera and psyllium laxative preparation in adult patients with constipation.


    Source

    Intestinal Diseases Unit, Soroka Medical Center, Beer Sheva, Israel. 

    ABSTRACT

    The aim of this study was to evaluate the effect of a novel laxative preparation, composed of celandin, aloevera and psyllium in patients with chronic constipation. Thirty-five men and women were randomized to receive capsules containing celandin-aloevera-psyllium, or placebo, in a double-blind trial lasting 28 days. Symptoms in the last 2 weeks of the treatment period were compared to those in the 14-day pre-trial basal period. In the celandin, aloevera and psyllium group, bowel movements became more frequent, the stools were softer and laxative dependence was reduced. In the placebo group, all these parameters were unchanged. Abdominal pain was not reduced in either group. The results of this study show that the preparation is an effective laxative in the treatment of constipation. 

    III)A qualitative study of quality of life and the experience of complementary and alternative medicine in Korean women with constipation.


    Source

    Fayetteville State University, Fayetteville, NC, USA. peace-peace@hanmail.net 

    ABSTRACT

    Twelve percent of people worldwide report suffering from self-defined constipation. Women experience constipation three times more than men. Many people have used complementary and alternative medicine for constipation, but there is no qualitative research about this issue. The purpose of this article was to describe Korean women's experience of treating chronic constipation with complementary and alternative medicine. A qualitative descriptive approach used in-depth, semistructured interviews with 10 Korean women in the United States who had constipation. Four themes were identified: (1) subjective definition of constipation; (2) efforts to find the reason for constipation; (3) efforts to find solutions for constipation (subtheme: frequent use of enemas, laxatives, and suppositories; expectation and disappointment for complementary and alternative medicine; finding individually effective solutions for constipation); and (4) negative impact on quality of life (subtheme: mental discomfort, changed appetite, and difficult relationships with people).Ten women reported that they had used exercise, massage, yogurt, vegetables, seeds of tangles (seaweed), mineral oil, milk with plums, mixed rice, walnuts, grapefruits, apples, oranges, aloe, oatmeal, soymilk, sweet potatoes, ground flax seed, and alcohol as a strategy for relieving constipation. Participants had also used herbs, acupuncture, acupressure, moxibustion, cupping therapy, hand acupuncture, senna tea, and soy bean past fomentation. In conclusion, living with constipation is an irritable and uncomfortable experience, and it motivated these women to select a variety of methods to reduce constipation. 

    IV) Toxicological evaluation of aqueous extract of Aloe ferox Mill. in loperamide-induced constipated rats.


    Source

    Department of Botany, University of Fort Hare, Alice, South Africa. 

    ABSTRACT

    Aloe ferox Mill. is a widely used medicinal plant in South Africa for the treatment of many ailments including constipation. The present study evaluated the toxicological effect of aqueous leaf extract of the herb at 50, 100 and 200 mg/kg body weight for 7 days on the haematological parameters as well as liver and kidney function indices in loperamide-induced constipated rats. The extract did not cause any significant (p > 0.05) effect on the kidney and liver-body weight ratio as well as the kidney function indices including serum levels of creatinine, uric acid, urea, calcium and potassium ions at all the dosages investigated. Whereas the serum levels of total protein, albumin, bilirubin and gamma glutamyl trasferase (GGT) were not affected, the elevated activities of alkaline phosphatase (ALP), alanine transaminase (ALT) and aspartate transaminase (AST) in the untreated constipated animals were normalized following treatment with extract. The data obtained with respect to the haematological analysis indicated that the extracts had no significant (p > 0.05) effect on the haematological parameters with the exception of lymphocyte count which was increased in the untreated constipated rats. This was however attenuated after administering the herb. The available evidence in this study suggests that A. ferox may be safe as an oral remedy for constipation. Generally, the effect of the extract compared favourably well with senokot, a recommended drug for the treatment of constipation. 

     







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