LaxaFresh

NPN:

80035902

Quantity:

100 VegeCaps

Product Type:

Aloe, Senna, +

Cautions & Warnings:

Consult a physician prior to use if you are taking prescription medications, have stomach ulcers/inflammation, have gall bladder disease or intestinal obstruction. Do not use if you are pregnant or breastfeeding, have intestinal, abdominal, rectal or colon problems, appendicitis, severe dehydration, diarrhoea, heart disease, high/low blood pressure, kidney or liver disorder, diabetes or edema or if you are taking products containing diuretics. If hypersensitivity occurs or if symptoms persist/worsen, discontinue use. Keep out of reach of children.

Biogenique Structurally Active-Orthogenic (SAO) technology

Vitamin B6 must be obtained from the diet and supplements because humans cannot synthesize it. There are three traditionally considered forms of vitamin B6: pyridoxal (PL), pyridoxine (PN), pyridoxamine (PM). The phosphate ester derivative pyridoxal 5’-phosphate (PLP) is the principal coenzyme form. SAO technology in Biogenique vitamin B-6 supplements stimulates the production of PLP in the human body, promoting the function of approximately 100 enzymes that catalyze essential chemical reactions. Our research says, pyridoxine deficiency in children principally affects the cognition (writing, learning and language skills), peripheral nerves, skin, mucous membranes, circulatory (blood cell) system and respiratory system. 

SAO Analysis - Pyridoxine functions:

Nervous system function
In the brain, the synthesis of several neurotransmitters, enzymes and chemicals that carry signals from one nerve cell to another is catalyzed by a PLP-dependent enzyme. Vitamin B6 helps in production of hormones like serotonin, epinephrine and melatonin which influence our mood, appetite, body clock (sleep patterns) and sensitivity to pain. 

Red blood cell formation
PLP functions as a coenzyme in the synthesis of heme, an iron-containing component of hemoglobin. Hemoglobin is found in red blood cells and is essential to transport oxygen throughout the body. PLP are able to bind to the hemoglobin molecule and affects its ability to pick up and release oxygen. 

Niacin (vitamin B3) formation
The human requirement of another B vitamin, niacin, can be met in part by conversion of the essential amino acid, tryptophan, to niacin with the help of coenzyme PLP. Thus adequate vitamin B6 decreases the requirement for dietary niacin 

Scientific Evidence

Seizures

Pyridoxine-dependent seizures in newborns can result from the use of high-dose pyridoxine in pregnant mothers or from autosomal recessive (genetic) pyridoxine dependency. Refractory seizures in newborns that are caused by pyridoxine dependence may be controlled quickly with intravenous administration of pyridoxine by a qualified healthcare provider. 

Cognitive function

Micronutrient status can affect cognitive function at all ages. Vitamin deficiencies could influence memory function and might contribute to age-associated cognitive impairment and dementia. Vitamin B6, comprising three chemically distinct compounds pyridoxal, pyridoxamine, and pyridoxine, is involved in the regulation of mental function and mood. Vitamin B6 is also an essential homocysteine re-methylation cofactor, and deficiency is associated with increase in blood homocysteine levels. Homocysteine is a risk factor for cerebrovascular disease and may also have directly toxic effects on neurons of the central nervous system. Neuropsychiatric disorders including seizures, migraine, chronic pain and depression have been linked to vitamin B6 deficiency. 

Immune system health

Vitamin B6 is important for immune system function, such as for production of antibodies. Decreased production of immune system cells known as lymphocytes, as well as decreased production of an important immune system protein called interleukin-2, have been reported in vitamin B6 deficient individuals. Restoration of vitamin B6 status has resulted in normalization of lymphocyte proliferation and interleukin-2 production, suggesting that adequate vitamin B6 intake is important for optimal immune system function 

Autism

One double-blind, placebo-controlled crossover study found indications that very high doses of vitamin B6 may produce beneficial effects in the treatment of autism. It has been suggested that combining magnesium with vitamin B6 could offer additional benefits, such as reducing side effects or allowing a reduced dose of the vitamin. Further research is needed. Autism should be treated by a qualified healthcare provider. 

Attention deficit hyperactivity disorder

ADHD is characterized by attention deficit, impulsivity, and sometimes over activity ("hyperactivity"). ADHD begins in childhood and often persists into adulthood. The exact etiology is unknown; genetics plays a role, but major etiologic contributors also include adverse responses to food additives, intolerances to foods and sensitivities to environmental chemicals, molds, and fungi. Research suggests that nutrient deficiencies are common in ADHD; but when individually managed with pyridoxine supplementation alone or in combination with other vitamins and minerals, dietary modification, detoxification and other features of a wholistic/integrative program of management can ameliorate ADHD symptoms helping the ADHD subject lead a normal and productive life. 

Asthma

Preliminary research suggests that children with severe asthma may have inadequate pyridoxine status. A double-blind study of 76 children with asthma found significant benefit from vitamin B6 after the second month of usage. Children in the vitamin B6 group were able to reduce their doses of asthma medication (bronchodilators and steroids). However, the dosages of B6 used in these studies were quite high, in the range of 200 to 300 mg daily. Because of the risk of nerve injury, it is not advisable to take this much B6 without medical supervision. 

Selected references

1. McCormick D. Vitamin B6. In: Bowman B, Russell R, eds. Present Knowledge in Nutrition. 9th ed. Washington, DC: International Life Sciences Institute; 2006.

2. Albert CM, Cook NR, Gaziano JM, et al. Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial. JAMA 2008 May 7; 299(17):2027-36.

3. Homocysteine Lowering Trialists' Collaboration. Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am J Clin Nutr. 2005 Oct; 82(4):806-12.

4. Miodownik C, Lerner V, Vishne T, et al. High-dose vitamin B6 decreases homocysteine serum levels in patients with schizophrenia and schizoaffective disorders: a preliminary study. Clin Neuropharmacol 2007 Jan-Feb; 30(1):13-7.

5. Schnyder G, Roffi M, Flammer Y, et al. Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trial. JAMA 8-28-2002; 288(8):973-979.

6. Sharma P, Kulshreshtha S, Singh GM, et al. Role of bromocriptine and pyridoxine in premenstrual tension syndrome. Indian J Physiol Pharmacol 2007 Oct-Dec; 51(4):368-74.

7. Whelan AM, Jurgens TM, Naylor H. Herbs, vitamins and minerals in the treatment of premenstrual syndrome: a systematic review. Can J Clin Pharmacol. 2009 Fall; 16(3):e407-29.

8. Trabetti E. Homocysteine, MTHFR gene polymorphisms, and cardio-cerebrovascular risk. J Appl Genet 2008; 49(3):267-82.

9. Selhub J. Public health significance of elevated homocysteine. Food Nutr Bull 2008 Jun; 29(2 Suppl):S116-25.

10. Matthews A, Dowswell T, Haas DM, Doyle M, O'Mathúna DP. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev. 2010 Sep 8 ;( 9):CD007575. 

I)Atypical Vitamin B6 Deficiency: A Rare Cause of Unexplained Neonatal and Infantile Epilepsies.

Source

Department of Neuropediatrics, University Medical Center Schleswig-Holstein, Kiel, Germany 

ABSTRACT

ALDH7A1 and PNPO deficiencies are rare inborn errors of vitamin B6 metabolism causing perinatal seizure disorders. The phenotypic variability, however, is broad. To assess the frequency of these deficiencies in unexplained infantile epilepsy, we screened 113 patients for mutations in both genes. We identified 1 patient with an epilepsy phenotype resembling Dravet syndrome and likely pathogenic mutations in ALDH7A1. Presenting features were highly atypical of pyridoxine-dependent epilepsy, including febrile seizures, response to anticonvulsive drugs, and periods of seizure freedom without pyridoxine treatment. "Hidden" vitamin B6 deficiencies might be rare but treatable causes of unexplained epilepsy extending beyond the classical phenotypes. 

II)) Effectiveness of nutritional supplements for reducing symptoms in autism-spectrum disorder: a case report.

Source

Department of Physical Therapy, Creighton University, Omaha, NE 68178, USA. RuiPingXia@creighton.edu 

ABSTRACT

OBJECTIVE: 

This report presents a case of a 9-year-old boy with autism that responded positively to nutritional supplements. 

METHODS: 

The supplements were dimethyl glycine and a combination of a large dose of vitamin B6 (pyridoxal HCl) and magnesium. The Autism Treatment Evaluation Checklist (ATEC) was used for outcome assessment and administered by 2 of his family members both before the nutritional supplements and 5 months into the supplements, thereby referred to as pretest and post-test, respectively. Two (2) assessors independently performed evaluations. The ATEC evaluates four areas: communication, sociability, sensory/cognitive awareness, and behavior. The lower the scores are, the less severe the symptoms are. 

RESULTS: 

The ATEC evaluations by 2 independent assessors showed that the changes in total ATEC were from 63 at pretest to 33 at post-test, and from 64 at pretest to 30 at post-test, respectively. These changes represented reductions of 47.6% and 53.1%. A strong inter-rater reliability was demonstrated, with an intraclass correlation coefficient of 0.988. The school teachers also noticed improvements in various areas consistent with the ATEC evaluations. 

CONCLUSION: 

Although the reported findings cannot be generalized, this case report provides useful preliminary evidence to an accumulating body of literature supporting the theory and efficacies of nutritional supplements in autism-spectrum disorders. 

III)Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. I. Attention deficit hyperactivity disorders. Mousain-Bosc M, Roche M, Polge A, Pradal-Prat D, Rapin J, Bali JP.

Source

Explorations Fonctionnelles du Système Nerveux, Centre Hospitalier Universitaire Carémeau, Nîmes, France. 

ABSTRACT

Some previous studies have reported the involvement of magnesium (Mg) deficiency in children with ADHD syndrome. In this work, 40 children with clinical symptoms of ADHD were followed clinically and biologically during a magnesium-vitamin B6 (Mg-B6) regimen (6 mg/kg/d Mg, 0.6 mg/kg/d vit-B6) which was set up for at least 8 weeks. Symptoms of ADHD (hyperactivity, hyperemotivity/ aggressiveness, lack of attention at school) were scored (0-4) at different times; in parallel, intraerythrocyte Mg2+ (Erc-Mg) and blood ionized Ca2+ (i-Ca) were measured. Children from the ADHDgroup showed significantly lower Erc-Mg values than control children (n = 36). In almost all cases of ADHD, Mg-B6 regimen for at least two months significantly modified the clinical symptoms of the disease: namely, hyperactivity and hyperemotivity/aggressiveness were reduced, school attention was improved. In parallel, the Mg-B6 regimen led to a significant increase in Erc-Mg values. When the Mg-B6 treatment was stopped, clinical symptoms of the disease reappeared in few weeks together with a decrease in Erc-Mg values. This study brings additional information about the therapeutic role of a Mg-B6 regimen in children with ADHD symptoms. 

IV) Vitamin B-complex initiates growth and development of human embryonic brain cells in vitro. Danielyan KE, Abramyan RA, Galoyan AA, Kevorkian GA

Source

G. Bunyatyan Institute of Biochemistry, National Academy of Sciences of Armenia, Yerevan, Armenia. Kristine_danielyan@biochem.sci.am 

ABSTRACT

We studied a combined effect of subcomponents of vitamin B complex on the growth, development, and death of human embryonic brain-derived cells (E90) cultured using a modified method of Matson. Cell death was detected by trypan blue staining. According to our results, vitamin B-complex in low-doses promote the development, maturation, and enlargement of human embryonic brain cells, on the one hand, and increases the percent of cell death, which attests to accelerated maturation and metabolism, on the other. 

V) Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses. Maggini S, Wintergerst ES, Beveridge S, Hornig DH.

Source

Bayer Consumer Care Ltd, Peter Merian-Strasse 84, P.O. Box, 4002 Basel, Switzerland. silvia.maggini.sm@bayer.ch 

ABSTRACT

Adequate intakes of micronutrients are required for the immune system to function efficiently. Micronutrient deficiency suppresses immunity by affecting innate, T cell mediated and adaptive antibody responses, leading to dysregulation of the balanced host response. This situation increases susceptibility to infections, with increased morbidity and mortality. In turn, infections aggravate micronutrient deficiencies by reducing nutrient intake, increasing losses, and interfering with utilization by altering metabolic pathways. Insufficient intake of micronutrients occurs in people with eating disorders, in smokers (active and passive), in individuals with chronic alcohol abuse, in certain diseases, during pregnancy and lactation, and in the elderly. This paper summarizes the roles of selected vitamins and trace elements in immune function. Micronutrients contribute to the body's natural defences on three levels by supporting physical barriers (skin/mucosa), cellular immunity and antibody production. Vitamins A, C, E and the trace element zinc assist in enhancing the skin barrier function. The vitamins A, B6, B12, C, D, E and folic acid and the trace elements iron, zinc, copper and selenium work in synergy to support the protective activities of the immune cells. Finally, all these micronutrients, with the exception of vitamin C and iron, are essential for antibody production. Overall, inadequate intake and status of these vitamins and trace elements may lead to suppressed immunity, which predisposes to infections and aggravates malnutrition. Therefore, supplementation with these selected micronutrients can support the body's natural defence system by enhancing all three levels of immunity. 

VI) Seizures with decreased levels of pyridoxal phosphate in cerebrospinal fluid. Goyal M, Fequiere PR, McGrath TM, Hyland K.

Source

Department of Pediatric Neurology, University of Alabama, Birmingham, AL 35233, USA. mgoyal@peds.uab.edu 

ABSTRACT

Although pyridoxine-dependent seizures have been reported for decades, pyridoxamine phosphate oxidase deficiency has only been recently described. Pyridoxamine phosphate oxidase (PNPO) is one of a series of enzymes involved in converting pyridoxine to pyridoxal 5'-phosphate, the biologically active form of pyridoxine. PNPO deficiency is associated with decreased levels of pyridoxal 5'-phosphate in CSF, as well as epilepsy. We describe four children up to 16 years of age with intractable seizures who all had low cerebrospinal fluid (CSF) levels of pyridoxal 5'-phosphate. Only one of the four children possessed a genetic alteration, a novel homozygous variant in exon one of the PNPO gene. Three of four, however, showed at least some clinical improvement with pyridoxal 5'-phosphate supplementation. Low CSF pyridoxal 5'-phosphate levels, although considered a diagnostic biomarker for PNPO deficiency, lack specificity and may result from multiple other causes. Genetic testing and CSF evaluation, along with clinical response are all necessary for accurate diagnosis. 

VII) Low intake of B-vitamins is associated with poor adolescent mental health and behavior. Herbison CE, Hickling S, Allen KL, O'Sullivan TA, Robinson M, Bremner AP, Huang RC, Beilin LJ, Mori TA, Oddy WH.

Source

Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Australia. 

ABSTRACT

OBJECTIVE: 

The current prevalence of mental health problems in Western populations is approximately 20% and half of all adult mental health disorders are estimated to originate in adolescence. Diet plays an important role in modulating psychological wellbeing and B-vitamins are vital for the synthesis of neurotransmitters such as serotonin. We aimed to examine the relationship between B-group vitamins and adolescent mental health and behavior. 

METHODS: 

This is a cross-sectional analysis of the West Australian Pregnancy Cohort (Raine) Study. The 17-year follow-up included collection of a food frequency questionnaire allowing B-vitamin intake calculation. Mental health was assessed using the Youth Self Report (YSR) which measures total, internalising (withdrawn/depressed) and externalising (aggressive/delinquent) behavior scores. Multiple linear regression was used to analyse associations between B-vitamins and mental health with adjustment for relevant confounders (n=709). 

RESULTS: 

Lower intake of vitamins B1, B2, B3, B5, B6, and folate was associated with higher externalising behaviour scores (p ≤ 0.05). Reduced intake of vitamin B6 and folate was associated with higher internalising behaviour scores (p ≤ 0.05). 

CONCLUSION: 

Poor nutrition may contribute to the pathogenesis of mental health problems in adolescence. The role of B-vitamins requires further investigation in randomized controlled trials.