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Vitamin C 1000TM

Potent Antioxidant

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100 Tablets  1000mg Vitamin C

  • Helps fight the common cold*
  • Powerful antioxidant*
  • Promotes healthy gums and teeth*

 

• Immune booster that protects your body from infections
• Aids in the prevention and treatment of the common cold
• Powerful antioxidant that prevents damage from free radicals
• Boosts iron absorption
• Helps wounds to repair quickly
• Promotes healthy gums and teeth
• Protects against scurvy 

Despite it’s essence to human health and the immune system, Vitamin C is a water-soluble vitamin, meaning it is difficult for the body to store it. To tackle this and prevent catching colds, it should be replenished daily with food or supplements. Jensens Vitamin C offers a simple, easy natural solution to maintaining healthy levels of this important vitamin in the blood. 

Why Jensens?


The application of Structurally Active-Orthogenic (SAO) technology by Jensense’s research and production team ensures that all available products are of a heightened quality. 

SAO technology produces active ingredients with strong molecular composition and the highest bioavailability (ratio of inactive/active ingredients) in order to ensure synergistic applications occur within the body. In other words, the Jensens label ensures that all our products are able to be optimally absorbed by the bloodstream at the molecular level, and don’t just pass through the body undigested. 

Jensens is pharmaceutically tested and clinically verified by careful examination at every stage of production. The protocols are measured and confirmed for international standard compliance before the product is introduced to market. 

Jensens only uses 100% natural ingredients. 




Active Ingredients


Vitamin C (Ascorbic Acid)…………………………………………………….1000mg

 

 





Vitamin C 1000TM

 

NPN:

 

80032192 

 

Quantity:


100 Tablets

 

 

Non Medicinal Ingredients:

 

Vegetable calcium phosphate dibasic, vegetable methyl cellulose, vegetable xanthan gum, vegetable stearic acid, rose hips, vegetable silica, vegetable magnesium stearate.

 

This Product Does Not Contain:


Gelatin, gluten, sugar, dairy or preservatives. 

Recommended Use:

 

An antioxidant for the maintenance of good health. 

 

Recommended Dose:


Adults: Take 1 tablet daily.

Risk Information:

 

Cautions & Warnings:

 

Keep out of reach of children. 
 

Storage:


• Seal for tamper resistant protection.
• If Seal is broken do not use.
• Store at room temperature 15-30 C
• Protect from Moisture 

download monograph

 

 





Biogenique Structurally Active-Orthogenic (SAO) technology


Vitamin C is a water-soluble vitamin. Unlike most mammals and other animals, humans do not have the ability to make their own vitamin C. Therefore, we must obtain vitamin C through our diet and supplements. Biogenique vitamin C supplements contains ascorbic acid essential to perform important functions in the body. Even in small amounts Biogenique vitamin C can protect indispensable molecules in the body, such as proteins, lipids (fats), carbohydrates from damage by free radicals.

Our Research says, Populations with low or no access to fruit or vegetables are at risk of vitamin C deficiency. Severe deficiency of vitamin C causes scurvy. The risk of scurvy is higher in women (especially pregnant women) than men and increases with age.

SAO Analysis


Ascorbic acid functions:
Ascorbic acid is required for the synthesis of collagen, an important structural component of blood vessels, tendons, ligaments, and bones. It also plays an important role in the synthesis of the neurotransmitter, norepinephrine. Neurotransmitters are critical to brain function and are known to affect mood. In addition, ascorbic acid is required for the synthesis of carnitine, a small molecule that is essential for the transport of fat into cellular organelles where the fat is converted to energy. Research also suggests that vitamin C is involved in the metabolism of cholesterol to bile acids, which may have implications for blood cholesterol levels and the incidence of gallstones.

Scientific Evidence


Common cold prevention

Scientific studies generally suggest that vitamin C does not prevent the onset of cold symptoms. However, in a subset of studies of people living in extreme climates or under extraordinary conditions, including soldiers in subarctic exercises, skiers, and marathon runners, vitamin C significantly reduced the risk of developing colds, by approximately 50%. This area merits more research and may be of particular interest to elite athletes or military personnel.

Role in Immunity

Vitamin C affects several components of the human immune system; for example, vitamin C has been shown to stimulate both the production and function of leukocytes (white blood cells), especially neutrophils, lymphocytes, and phagocytes. Neutrophils, which attack foreign bacteria and viruses, seem to be the primary cell type stimulated by vitamin C. Additionally, several studies have shown that supplemental vitamin C increases serum levels of antibodies and C1q complement proteins in guinea pigs, which—like humans—cannot synthesize vitamin C and hence depend on dietary vitamin C. Vitamin C may also protect the integrity of immune cells. Phagocytic leukocytes also produce and release cytokines which have antiviral activity. It is widely thought by the general public that vitamin C boosts the function of the immune system, and accordingly, may protect against viral infections and perhaps other diseases. While some studies suggest the biological plausibility of vitamin C as an immune enhancer, human studies published to date are conflicting. Further, controlled clinical trials of appropriate statistical power would be necessary to determine if supplemental vitamin C boosts the immune system.

Antioxidant

Vitamin C is also a highly effective antioxidant. Even in small amounts vitamin C can protect indispensable molecules in the body, such as proteins, lipids (fats), carbohydrates, and nucleic acids (DNA and RNA), from damage by free radicals and reactive oxygen species that can be generated during normal metabolism as well as through exposure to toxins and pollutants (e.g., cigarette smoke). Vitamin C may also be able to regenerate other antioxidants such as vitamin E. One recent study of cigarette smokers found that vitamin C regenerated vitamin E from its oxidized form. 

Stroke

Plasma vitamin C levels may be a good biomarker for fruit and vegetable intake and other lifestyle factors that contribute to a reduced risk of stroke. A recent prospective study in adults found that those in the top quartile of plasma vitamin C concentrations had a 42% lower risk of stroke compared to those in the lowest quartile. However, this study had numerous limitations that make it difficult to draw conclusions for the general population.

Cancer prevention

Dietary intake of fruits and vegetables high in vitamin C has been associated with a reduced risk of various types of cancer in population studies (particularly cancers of the mouth, esophagus, stomach, colon, or lung). Vitamin C has a long history of use as an adjunct in cancer therapy, and although there has not been any definite evidence of a benefit from injected or oral vitamin C, there is evidence that there is benefit in some cases. Some studies have examined a link between the consumption of fruits and vegetables rich in vitamin C and the prevention of breast cancer. Based on studies included in a review, the effects of vitamin C supplementation on the prevention of endometrial cancer are mixed. 

Coronary Heart Disease

Until recently, the results of most prospective studies indicated that low or deficient intakes of vitamin C were associated with an increased risk of cardiovascular diseases, and that modest dietary intakes of about 100 mg/day were sufficient for maximal reduction of cardiovascular disease risk among non-smoking men and women. Dietary restriction of vitamin C may be associated with increases in both diastolic and systolic blood pressure. Vitamin C supplementation has been shown to decrease systolic and diastolic blood pressure. Due to its antioxidant properties, vitamin C has been used in patients with ischemic heart disease. Early data suggest that vitamin C may have a benefit on blood flow in the heart, but more research is needed to confirm this finding.

Gallbladder disease

Vitamin C supplementation and increased vitamin C serum levels may decrease the risk of developing gallbladder disease in women. Well-designed trials are needed.

Lead toxicity

Abnormal growth and development have been observed in infants of women exposed to lead during pregnancy, while children who are chronically exposed to lead are more likely to develop learning disabilities, behavioral problems, and to have a low IQ. In adults, lead toxicity may result in kidney damage, high blood pressure, and anemia. Consuming vitamin C from dietary sources or supplementations may lower blood concentrations of lead. Additional studies are needed. The mechanism for the relationship between vitamin C intake and blood lead levels is not known, although it has been postulated that vitamin C may inhibit intestinal absorption or enhance urinary excretion of lead.

Asthma

It has been suggested that low levels of vitamin C (or other antioxidants) may increase the risk of developing asthma. The use of vitamin C for the treatment of asthma (particularly exercise-induced asthma) has been studied, although the evidence in this area remains inconclusive.

Iron absorption enhancement:

Based on scientific research, vitamin C appears to improve oral absorption of iron. Concurrent vitamin C may aid in the absorption of iron dietary supplements.

Arthritis (osteoarthritis and rheumatoid arthritis) 

Consumption of vitamin C may reduce the risk of cartilage loss and disease progression in individuals with osteoarthritis. However, more well-designed clinical trials are been conducted to determine if vitamin C is beneficial for osteoarthritis or rheumatoid arthritis.

Selected references


1. Bjelakovic G, Gluud LL, Nikolova D, et al. Meta-analysis: antioxidant supplements for liver diseases - the Cochrane Hepato-Biliary Group. Aliment Pharmacol Ther. 2010 Aug;32(3):356-67. 

2. Douglas RM, Hemilä H, Chalker E, et al. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev 2007 Jul 18;(3):CD000980. 

3. Duconge J, Miranda-Massari JR, et al. Vitamin C pharmacokinetics after continuous infusion in a patient with prostate cancer. Ann Pharmacother 2007 Jun;41(6):1082-3. 

4. Ehrlich M, Rao J, Pabby A, et al. Improvement in the appearance of wrinkles with topical transforming growth factor beta(1) and l-ascorbic acid. Dermatol Surg 2006 May;32(5):618-25. 

5. Hemilä H, Louhiala P. Vitamin C for preventing and treating pneumonia. Cochrane Database Syst Rev 2007 Jan 24;(1):CD005532. 

6. Inui S, Itami S. Perifollicular pigmentation is the first target for topical vitamin C derivative ascorbyl 2-phosphate 6-palmitate (APPS): randomized, single-blinded,placebo-controlled study. J Dermatol 2007 Mar;34(3):221-3. 

7. Jiang L, Yang KH, Tian JH, et al. Efficacy of antioxidant vitamins and selenium supplement in prostate cancer prevention: a meta-analysis of randomized controlled trials. Nutr Cancer. 2010 Aug;62(6):719-27. 

8. Konturek PC, Kania J, Hahn EG, et al. Ascorbic acid attenuates aspirin-induced gastric damage: role of inducible nitric oxide synthase. J Physiol Pharmacol 2006 Nov;57 Suppl 5:125-36. 

9. Lin J, Cook NR, Albert C, et al. Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial. J Natl Cancer Inst 2009 Jan 7;101(1):14-23. 

10. McNulty PH, Robertson BJ, Tulli MA, et al. Effect of hyperoxia and vitamin C on coronary blood flow in patients with ischemic heart disease. J Appl Physiol 2007 May;102(5):2040-5. 

11. Muran PJ. Mercury elimination with oral DMPS, DMSA, vitamin C, and glutathione: an observational clinical review. Altern Ther Health Med 2006 May-Jun;12(3):70-5. 

12. Nankivell BJ, Murali KM. Images in clinical medicine. Renal failure from vitamin C after transplantation.N Engl J Med 2008 Jan 24;358(4):e4. 

13. Ochoa-Brust GJ, Fernández AR, Villanueva-Ruiz GJ, et al. Daily intake of 100 mg ascorbic acid as urinary tract infection prophylactic agent during pregnancy. Acta Obstet Gynecol Scand 2007;86(7):783-7. 

14. Puvabanditsin P, Vongtongsri R. Efficacy of topical vitamin C derivative (VC-PMG) and topical vitamin E in prevention and treatment of UVA suntan skin. J Med Assoc Thai 2006 Sep;89 Suppl 3:S65-8. 

15. Zollinger PE, Tuinebreijer WE, Breederveld RS, et al. Can vitamin C prevent complex regional pain syndrome in patients with wrist fractures? A randomized, controlled, multicenter dose-response study. J Bone Joint Surg Am 2007 Jul;89(7):1424-31.

 






I) Vitamin C supplementation lowers serum low-density lipoprotein cholesterol and triglycerides: a meta-analysis of 13 randomized controlled trials.


Assistant Professor, Department of Physiology and Biochemistry, National University of Health Sciences, Lombard, IL 60148.

ABSTRACT

OBJECTIVE: 

Vitamin C has been shown to be an effective therapeutic for reducing total serum cholesterol, but epidemiologic studies have determined that low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol are actually better predictive measures of coronary heart disease risk. Therefore, the purpose of this study was to provide a comprehensive meta-analysis of randomized controlled trials to investigate the effect of vitamin C supplementation on LDL and HDL cholesterol as well as triglycerides in patients with hypercholesterolemia.

METHODS: 

Thirteen randomized controlled trials published between 1970 and June 2007 were identified using Medline and a manual search. From the 13 trials, 14 separate group populations with hypercholesterolemia and who were supplemented with at least 500 mg/d of vitamin C for between 3 and 24 weeks were entered into the meta-analysis. This meta-analysis used a random-effects model; and the overall effect sizes were calculated for changes in LDL and HDL cholesterol, as well as triglyceride concentrations.

RESULTS: 

The pooled estimate of effect for vitamin C supplementation on LDL and HDL cholesterol was -7.9 mg/dL (95% confidence interval [CI], -12.3 to -3.5; P = .000) and 1.1 mg/dL (95% CI, -0.2 to 2.3; not significant), respectively. The pooled estimate of effect for vitamin C supplementation on triglycerides was -20.1 mg/dL (95% CI, -33.3 to -6.8; P < .003).

CONCLUSION: 

Supplementation with at least 500 mg/d of vitamin C, for a minimum of 4 weeks, can result in a significant decrease in serum LDL cholesterol and triglyceride concentrations. However, there was a nonsignificant elevation of serum HDL cholesterol.

II) Ascorbic acid increases healing of excision wounds of mice whole body exposed to different doses of gamma-radiation.


Department of Radiobiology, Kasturba Medical College, Manipal 576104, India.

ABSTRACT

Because of the practical importance of acute radiation exposure associated with combined injuries, it is imperative to investigate the efficacy of cost-effective nutritional factors in the reconstruction of irradiated wounds. Therefore, effect of pretreatment of ascorbic acid was studied on the healing of excised wounds in mice exposed to 2, 4, 6 and 8 Gy whole body gamma-radiation. A full-thickness wound was created on the dorsum of the irradiated mice and the progression of wound contraction was monitored by capturing video images of the wound at various varying days after irradiation. Irradiation caused a dose dependent delay in wound contraction and wound healing time, while ascorbic acid pretreatment resulted in a significant acceleration in the rate of wound contraction and a decrease in the mean wound healing time. To understand the mechanism of healing, collagen, hexosamine, DNA, nitrite and nitrate contents were measured in the granulation tissue of wounded mice treated with ascorbic acid before exposure to 6 Gy gamma-radiation. Ascorbic acid treatment prior to irradiation enhanced the synthesis of collagen, hexosamine, DNA, nitrite and nitrate contents. The histological assessment of wound biopsy revealed an improved collagen deposition, and increase in fibroblast and vascular densities. The present study demonstrates that ascorbic acid pretreatment has a beneficial effect on the irradiated wound and could be a substantial therapeutic strategy to accelerate wound repair in irradiated wounds and in the cases of combined injury situations.

III) UStudy of the protective effect of ascorbic acid against the toxicity of stannous chloride on oxidative damage, antioxidant enzymes and biochemical parameters in rabbits.


Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt. yousefmokhtar@yahoo.com

ABSTRACT

Stannous chloride (SnCl2) is a reducing chemical agent used in several man-made products. SnCl2 can generate reactive oxygen species (ROS). Therefore, the present study has been carried out to investigate the antioxidant action of l-ascorbic acid (AA) in minimizing SnCl2 toxicity on lipid peroxidation, antioxidant enzyme, and biochemical parameters in male New Zealand white rabbits. Animals were assigned to one of four treatment groups: 0mg AA and 0mg SnCl2/kg BW (control); 40 mg AA/kg BW; 20mg SnCl2/kg BW; 20mg SnCl2 plus 40 mg AA/kg BW. Rabbits were orally administered the respective doses every other day for 12 weeks. Results obtained showed that SnCl2 significantly (P<0.05) induced thiobarbituric acid-reactive substances (TBARS; the marker of lipid peroxidation) in plasma, while the activities of glutathione S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT), and the level of sulfhydryl groups (SH-group) were decreased (P<0.05) in blood plasma. Aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (AlP), acid phosphatase (AcP) and lactate dehydrogenase (LDH) activities were decreased (P<0.05). Stannous chloride significantly (P<0.05) increased the levels of plasma total lipid (TL), cholesterol, triglyceride (TG), low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL), glucose, urea and total bilirubin. On the other hand, the level of plasma high-density lipoprotein (HDL), total protein (TP), albumin (A) and globulin (G) were significantly (P<0.05) decreased. Ascorbic acid alone significantly decreased the levels of TBARS, lipids and urea, and increased the activities of GST, SOD and CAT, and the levels of SH-group and proteins. While the rest of the tested parameters were not affected. Also, the presence of AA with SnCl2 alleviated its harmful effects on most of the tested parameters. Therefore, the present results revealed that treatment with AA could minimize the toxic effects of stannous chloride.






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