RobustFlex

NPN:

80085971

Quantity:

120 VegeCaps 

Product Type:

Collagen, Turmeric, +

Cautions & Warnings:

Consult a physician prior to use if you are pregnant or breastfeeding, if you have gallstones or a bile duct obstruction, stomach ulcers or excess stomach acid, asthma or peptic ulcer disease or if you are taking anticoagulants. Some people may experience mild gastrointestinal disturbances. In any case, discontinue use. Keep out of reach of children.

Biogenique Structurally Active-Orthogenic (SAO) technology

The B vitamins are a chemically related family of nutrients that work as a team. They are found in whole unprocessed foods, fruits and vitamin B12 is found only in animal foods and fortified foods. Thus, Vegetarians suffer from vitamin B12 deficiency and consequently pernicious anemia. Some of these nutrients help metabolize carbohydrates, proteins and fats for energy and others support tissue and red blood cell formation. To get the most benefits from any of B’s vitamin you need all of them. Biogenique SAO technology has designed B50 Complex comprising of all essential 8 vitamins of B-group in scientifically discerning ratios available. 

Our research says, 

Biogenique B50 complex is combination of officially recognized group of eight essential B vitamins. However, dispute arises with the number as some sources claims that there are in fact eleven vitamins within B-complex, yet within most official, academic and scientific authorities, the number is generally accepted as eight. They are as follows:

• Vitamin B1 (thiamine)
• Vitamin B2 (riboflavin)
• Vitamin B3 (niacin)
• Vitamin B5 (pantothenic acid)
• Vitamin B6 (pyridoxine)
• Vitamin B7 (biotin)
• Vitamin B9 (folic acid or folate)
• Vitamin B12 (cobalamin)

SAO Analysis

Vitamin B1 (thiamine):

Thiamine is involved in numerous body functions, including nervous system and muscle functioning; the flow of electrolytes in and out of nerve and muscle cells; multiple enzyme processes; carbohydrate metabolism; and the production of hydrochloric acid (which is necessary for proper digestion). Severe chronic thiamine deficiency (beriberi) can result in potentially serious complications involving the nervous system, brain, muscles, heart, and gastrointestinal system.

Dry beriberi
The main feature of dry (paralytic or nervous) beriberi is neuropathy. Early in the course of the neuropathy, "burning feet syndrome" may occur. Other symptoms include abnormal (exaggerated) reflexes, as well as diminished sensation and weakness in the legs and arms. Muscle pain and tenderness and difficulty rising from a squatting position have also been observed.

Wet beriberi
In addition to neurologic symptoms, wet (cardiac) beriberi is characterized by cardiovascular manifestations of thiamin deficiency, which include rapid heart rate, enlargement of the heart, severe swelling, difficulty breathing, and ultimately congestive heart failure.

Cerebral beriberi
Cerebral beriberi may lead to Wernicke's encephalopathy and Korsakoff's psychosis, especially in people who abuse alcohol. It involves a confused, apathetic state and a profound memory disorder, with severe amnesia and loss of recent and working memory. 

Vitamin B2 (riboflavin)
Riboflavin is primarily involved in energy production and helps vision and skin health. Alcoholics are at increased risk for riboflavin deficiency due to decreased intake, decreased absorption, and impaired utilization of riboflavin. 

Ariboflavinosis
Ariboflavinosis is the medical name for riboflavin deficiency. Symptoms includes an inflamed tongue (painful, smooth, purple-red tongue), cracks and redness in tongue and corners of the mouth, anxiety, inflamed eyelids and sensitivity to light, hair loss, reddening of the cornea and skin rash. 

Vitamin B3 (niacin)
Niacin is essential for body to convert carbohydrates, fat into energy. It helps maintain skin health and supports the nervous and digestive systems. 

Pellagra (niacin deficiency)
People who drink excessive amounts of alcohol or live on a diet almost exclusively based on corn are at risk of pellagra. Other causes are associated with digestive problems where body does not absorb niacin efficiently. The main symptoms of pellagra are commonly referred to as 3 D’s – dementia, diarrhea and dermatitis. Other symptoms include an inflamed and swollen tongue, irritability, loss of appetite, mental confusion, weakness and dizziness. This disease can lead to death if not treated. 

Vitamin B5 (pantothenic acid)
Pantothenic acid is needed to metabolize carbohydrates, proteins and fats as well as produce red blood cells and steroid hormones. Vitamin B5 deficiency is extremely rare. Symptoms include loss of appetite, fatigue and insomnia, constipation, vomiting and intestinal distress. 

Vitamin B6 (pyridoxine)
Pyridoxine is needed for protein and carbohydrate metabolism, maintains healthy immune system, helps formation of red blood cells and certain brain chemicals. It influences brain processes and development, immune function and steroid hormone activity. Vitamin B6 is useful in treatment of carpal tunnel syndrome, premenstrual syndrome (PMS) and Alzheimer’s disease. It control levels of Homocysteine in the blood and reduces heart diseases. 

Vitamin B7 (biotin)
This vitamin is needed for energy metabolism, fat synthesis, amino acid metabolism and glycogen synthesis. Biotin is widely distributed in foods and is only required in small amounts, so deficiency is very rare. Symptoms include pale or grey skin, cracked sore tongue, depression, hallucination, abnormal heart actions, loss of appetite, nausea, dry skin and scaly dermatitis, hair loss, muscle pain, weakness and fatigue. 

Vitamin B9 (folic acid or folate)
Folate is needed to form red blood cells, which carry oxygen around the body. It helps the development of the fetal nervous system, as well as DNA synthesis and cell growth. Women of child-bearing age need a diet rich in folate. If planning a pregnancy, you should consider taking Biogenique B50 complex supplements. This is important to reduce risks such as spina bifida in the baby. The symptoms of folate deficiency includes weight loss, tiredness, fatigue, weakness and folate-deficiency anemia i.e. megaloblastic anemia. 

Vitamin B12 (cobalamin)
Vitamin B12 helps to produce and maintain myelin surrounding nerve cells, mental ability, red blood cell formation and breaking down of some fatty acids and amino acids to produce energy. Vitamin B12 has close relationship with folate, as both depend on the other to work properly. Deficiency is most commonly found in elderly, vegans and breastfed babies of vegan mothers, and is called pernicious anemia. Symptoms include tiredness and fatigue, lack of appetite and weight loss, apathy and depression, anemia, smooth tongue and degeneration of peripheral nerves progressing to paralysis. 

Scientific Evidence

Strengthen the brains of elderly people

Distinct nutrient biomarker patterns detected in plasma are interpretable and account for a significant degree of variance in both cognitive function and brain volume. Objective and multivariate approaches to the study of nutrition in brain health warrant further study. 

3 B's Block Cardiovascular Disease

Current research suggests that the three B's—folic acid, B6 and B12—can control and reduce homocysteine levels, known to be high in case of cardiovascular disease. Folic acid seems to be the most important single nutrient in providing protection.

Niacin Helps Hearts 

Niacin (nicotinic acid), a B vitamin, is one of the oldest drugs used to treat high blood-cholesterol levels. Unlike its non-flushing counterpart, niacinamide, niacin displays potent LDL cholesterol- and triglyceride-lowering effects and HDL cholesterol-elevating effects. Niacin has also been shown to help reverse hardening of the arteries and to decrease the incidence of heart disease and its associated deaths, qualities that distinguish it from other dietary supplements.

Stress

The B vitamins are generally associated with brain and nervous-system function. Vitamin B6, pyridoxine, may affect mood by its ability to process beneficial series-one prostaglandins, which have a variety of roles in regulating cellular activities such as the inflammatory response.

Selected references

1. Nutrient biomarker patterns, cognitive function, and MRI measures of brain aging. Bowman GL, Silbert LC, Howieson D, Dodge HH, Traber MG, Frei B, Kaye JA, Shannon J, Quinn JF. Source Department of Neurology, Oregon Health & Science University, Portland, USA. bowmang@ohsu.edu

2. Guttormsen AB, et al. Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (>or=40 micromol/liter). The Hordaland Homocysteine Study. J Clin Invest 1996 Nov;98(9):2174-83.

3. One-year reduction and longitudinal analysis of carotid intima-media thickness associated with colestipol/niacin therapy Stroke. 1993 (Dec); 24 (12): 1779-83

4. Prevention of progression of coronary atherosclerosis by treatment of hyperlipidaemia: a seven-year prospective angiographic study Br Med J (Clin Res Ed). 1984 (Jul 28); 289 (6439): 220-3

5. Fifteen-year mortality in coronary drug project patients: long-term benefit with niacin J Am Coll Cardiol. 1986 (Dec); 8 (6): 1245-55

6. Do lipid lowering drugs reduce the risk of coronary heart disease? Crit Rev Clin Lab Sci. 1998 (Dec); 35 (6): 603-21. Review

7. Henrotte JG, et al. Effect of pyridoxine on mice gastric ulcers and brain catecholamines after an immobilization stress. Ann Nutr Metab 1992;36(5-6):313-7.

8. Lindenbaum ES, et al. Effects of pyridoxine on mice after immobilization stress. Nutr Metab 1974;17(6):368-74.

I)Systematic administration of B vitamins attenuates neuropathic hyperalgesia and reduces spinal neuron injury following temporary spinal cord ischaemia in rats.

Source

Institute of Neurosciences, The Fourth Military Medical University, Xi'an, China. 

ABSTRACT

BACKGROUND: 

B vitamins have been demonstrated to be effective in treating chronic pain due to peripheral nerve injury. We investigated whether B vitamins could alleviate neuropathic pain and reduce neuron injury following temporary ischaemia in a rat model of spinal cord ischaemia-reperfusion injury (SCII). 

METHODS: 

SCII was produced by transiently blocking the unilateral lumbar arteries in adult male Sprague-Dawley rats. Behavioural and neurochemical signs of neuropathic pain and spinal neuron injury were analysed with and without B vitamin treatment. 

RESULTS: 

SCII caused behavioural thermal hyperalgesia and mechanical allodynia and neurochemical alterations, including increased expression of the vanilloid receptor 1 (VR1) and induction of c-Fos, as well as activation of the astrocytes and microglial cells in the spinal cord. Repetitive systemic administration of vitamin B complex (B1/B6/B12 at 33/33/0.5 mg/kg, i.p., daily, for 7-14 consecutive days) significantly reduced thermal hyperalgesia and the increased expression of VR1 and c-Fos, as well as activation of the astrocytes and microglial cells. SCII caused a dramatic decrease of the expression of the rate-limiting enzyme glutamic acid decarboxylase-65 (GAD65), which synthesizes γ-aminobutyric acid (GABA) in the axonal terminals, and β-III-tubulin, and also caused loss of Nissl bodies in the spinal cord. These alterations were largely prevented and rescued by the B vitamin treatment. 

CONCLUSION: 

These findings support the idea that the B vitamins are capable of neuroprotection and antinociception during spinal cord injury due to temporary ischaemia. Rescuing the loss of inhibitory GABAergic tone may reduce spinal central sensitization and contribute to B vitamin-induced analgesia. 

II)The effect of methylated vitamin B complex on depressive and anxiety symptoms and quality of life in adults with depression.

Source

Department of Psychiatry & Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. 

ABSTRACT

Depression, the most common type of mental illness, is the second leading cause of disability and is increasing among Americans. The effect of improved nutrition, particularly with dietary supplements, on depression may provide an alternative to standard medical treatment. Some studies have shown that certain nutrients (e.g., inositol and S-adenosyl methionine) are effective at improving depressed mood, although the results are not unequivocal. The current study was a randomized, double-blind, placebo-controlled trial to evaluate the efficacy of a vitamin B complex nutritional supplement (Max Stress B) for improving depressive and anxiety symptoms according to the Beck Depression and Anxiety Inventories (BDI and BAI) in 60 adults diagnosed with major depression or other forms of depressive disorders. Secondary outcomes included quality of life according to the SF-36. Participants were assessed at baseline and 30- and 60-day followups. Max Stress B showed significant and more continuous improvements in depressive and anxiety symptoms, compared to placebo. Additionally, Max Stress B showed significant improvement on the mental health scale of the SF-36 compared to placebo. Thus, we showed modest utility of Max Stress B to improve mood symptoms and mental health quality of life in adults with depression. 

III)Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment.

Source

Functional Magnetic Resonance Imaging of the Brain (FMRIB) Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom. douaud@fmrib.ox.ac.uk 

ABSTRACT

Is it possible to prevent atrophy of key brain regions related to cognitive decline and Alzheimer's disease (AD)? One approach is to modify nongenetic risk factors, for instance by lowering elevated plasma homocysteine using B vitamins. In an initial, randomized controlled study on elderly subjects with increased dementia risk (mild cognitive impairment according to 2004 Petersen criteria), we showed that high-dose B-vitamin treatment (folic acid 0.8 mg, vitamin B6 20 mg, vitamin B12 0.5 mg) slowed shrinkage of the whole brain volume over 2 y. Here, we go further by demonstrating that B-vitamin treatment reduces, by as much as seven fold, the cerebral atrophy in those gray matter (GM) regions specifically vulnerable to the AD process, including the medial temporal lobe. In the placebo group, higher homocysteine levels at baseline are associated with faster GM atrophy, but this deleterious effect is largely prevented by B-vitamin treatment. We additionally show that the beneficial effect of B vitamins is confined to participants with high homocysteine (above the median, 11 µmol/L) and that, in these participants, a causal Bayesian network analysis indicates the following chain of events: B vitamins lower homocysteine, which directly leads to a decrease in GM atrophy, thereby slowing cognitive decline. Our results show that B-vitamin supplementation can slow the atrophy of specific brain regions that are a key component of the AD process and that are associated with cognitive decline. Further B-vitamin supplementation trials focusing on elderly subjets with high homocysteine levels are warranted to see if progression to dementia can be prevented.