(0)Items in cart View Checkout


About UsContactFAQ

Cell SupportTM

Advanced Antioxidant Support

$62.37


30 Veg Caps     with 22.5 mg of Delta                           Tocotrienol

  • Promotes cardiac health*
  • Promotes anti-aging and fights cholesterol*
  • Protects against nerve injury and degradation*
  • Tab 1

     

    • Contains Tocotreinol, a powerful, natural “super” antioxidant 
    • Promotes anti-aging
    • Inhibits liver cholesterol production, lowering total blood cholesterol
    • Reverses arterial blockage, reducing risk of cardiovascular diseases
    • Protects against heart injury (ischemic or reperfusion)
    • Prevents blood clotting (inhibits platelet aggregation)
    • Neuroprotection: protects nerves from degradation, helping to prevent stroke like injuries to the brain
    • Promotes healthy blood pressure
    • Anti-Cancer Properties (fights against abnormal cell growth) 

    Biogenique Antioxidant Support contains high quantities of Tocotrienols, which are 50 times more powerful than normal Tocopherol antioxidants. In addition to normal properties, Tocotrienols promote healthy cellular structure, improved cognitive function, enhanced immunity and act as free radical scavengers which aids in the prevention of cancerous cells. 

    Why Biogenique?


    The application of Structurally Active-Orthogenic (SAO) technology by Biogenique’s research and production team ensures that all available products are of a heightened quality. 

    SAO technology produces active ingredients with strong molecular composition and the highest bioavailability (ratio of inactive/active ingredients) in order to ensure synergistic applications occur within the body. In other words, the Biogenique label ensures that all our products are able to be optimally absorbed by the bloodstream at the molecular level, and don’t just pass through the body undigested. 

    Biogenique is pharmaceutically tested and clinically verified by careful examination at every stage of production. The protocols are measured and confirmed for international standard compliance before the product is introduced to market. 

    Biogenique only uses 100% natural ingredients. 




    Tab 1

    Active Ingredients


    Gamma-Tocotrienol........................................2.5 mg 
    Delta-Tocotrienol............................................22.5 mg 
    Lecithin.........................................................210 mg

     

     







    Tab 3

    Cell SupportTM

     

    NPN:

     

    80043225 

    Quantity:

     

    30 Veggie Capsules

     

     

    Non Medicinal Ingredients:


    Rice bran oil, vegetable hypromellose.

    This Product Does Not Contain:


    Gelatin, sugar, dairy or preservatives. 

    Recommended Use:


    Provides antioxidants.

    Recommended Dose:


    Adults: Take 1 capsule 3 times daily.

    Risk Information:

     

    Cautions & Warnings:


    If you are pregnant or breastfeeding, consult a health care practitioner prior to use.

    Keep out of reach of children.

    Contraindications:


    Consult a physician before use if you are taking HMG-CoA reductase inhibitors.

    Storage:


    • Seal for tamper resistant protection.
    • If Seal is broken do not use.
    • Store at room temperature 15-30 C
    • Protect from Moisture 

    download monograph

     





    Tab 3

    Tab 3 Content

    Tab 1

    Background


    Vitamin E exists in eight different forms: four tocopherols (alpha-, beta-, gamma-, and delta-) and four tocotrienols (alpha-, beta-, gamma-, and delta-). Tocotrienols play an important role in many of the beneficial functions of the vitamin, ranging from protecting cell membranes to combating free radicals. Tocotrienols share identical structure with the tocopherols except for the addition of three double bounds to their side chains. Specifically, symptoms caused by alpha-tocopherol deficiency can be alleviated by tocotrienols. Thus, tocotrienols may be viewed as being members of the natural vitamin E family not only structurally but also functionally. 

    Biogenique Structurally Active-Orthogenic (SAO) technology


    Free radicals are unstable molecules with uneven number of electrons and is constantly searching to bond with other molecules to gain that electron. Our body generates hundreds of substances called "free radicals" when converting food to energy. Most of us have way too many free radicals due to environmental factors like pollution, radiation, smoking or inhaling smoke, pesticides, herbicides, and stress. 

    Free radicals are responsible for:
    ? Accelerated aging
    ? Destruction of DNA
    ? Clogging of arteries
    ? Tissue damage
    Biogenique SAO technology formulates the active ingredients with phytochemicals, vitamins, enzymes and other nutrient dense substances that disarm the free radicals by donating an electron particles. The Biogenique Antioxidant Support fights with free radicals and terminate the chain reaction before vital molecules are damaged. It has the potential to improve or prevent a number of chronic diseases. SAO technology extracts the principal antioxidant (tocotreinol) in Antioxidant Support formula from oils that are found in plants, hence it is pure and natural. A combination of the most well-researched and powerful antioxidants, Biogenique Antioxidant support is a convenient way to support overall health and strengthen resistance to degenerative diseases. Each antioxidant in this formula protects cell membranes from the effects of pollution, unhealthy lifestyle choices and the ravages of aging. They also help to regenerate each other for increased antioxidant protection. 

    SAO Analysis


    Tocotreinols functions:
    Tocotrienols are forms of natural vitamin E that can protect against brain cell damage, prevent cancer and reduce cholesterol. These biological characteristics, however, are not present in tocopherols. The unsaturated side-chain in tocotrienols causes them to penetrate tissues with saturated fatty layers more efficiently. All of the tocotrienol and tocopherol isomers have this antioxidant activity due to the ability to donate a hydrogen atom (a proton plus electron) from the hydroxyl group on the chromanol ring, to a free radical in the body. This process inactivates ("quenches") the free radical by effectively donating a single unpaired electron (which comes with the hydrogen atom) to the radical. 

    Scientific Evidence


    Works as a super Antioxidant

    Tocotrienols are also potent antioxidants that can combat free radicals in the human body and boost the immune system. It is known that alpha tocotrienols are 40 to 60 times more powerful than alpha-tocopherols as antioxidants in preventing lipid peroxidation. Many athletes and bodybuilders use tocotrienols to prevent lipid peroxidation and protein oxidation after strenuous exercise sessions 

    Slows aging and protects skin

    When applied topically onto the skin, tocotrienols gather at the skin’s stratum corneum, and they form the first line of defense against the free radicals that are generated by ultraviolet or ozone rays. As such, they can prevent skin damage and aging that are caused by unhealthy rays from the sun. By eliminating free radical activities, tocotrienols also help to maintain a healthy level of tocopherols, which are essential in the prevention of skin damage. It has been found that skin that is treated with tocotrienols show very high concentrations of vitamin E, which is beneficial to skin health. 

    Heart Disease and Antioxidants

    Vitamin E, beta-carotene, and other so-called antioxidants aren’t the silver bullet against heart disease and stroke that researchers were hoping for. Although the final chapter has not been written on vitamin E.
    In the Women’s Health Study, 39,876 initially healthy women took 600 IU of natural source vitamin E or a placebo every other day for 10 years. At the study’s end, the rates of major cardiovascular events and cancer were no lower among those taking vitamin E than they were among those taking the placebo. However, the trial did observe a significant 24 percent reduction in total cardiovascular mortality. Although this was not a primary endpoint for the trial, it nevertheless represents an extremely important outcome. (2)
    However, some studies suggest potential benefits among certain subgroups. A recent trial of vitamin E in Israel, for example, showed a marked reduction in coronary heart disease among people with type 2 diabetes who have a common genetic predisposition for greater oxidative stress.
    What about combinations? The findings are complicated and not entirely clear. In the Supplementation French men and women took a single daily capsule that contained 120 milligrams of vitamin C, 30 milligrams of vitamin E, 6 milligrams of beta-carotene, 100 micrograms of selenium, and 20 milligrams of zinc, or a placebo, for seven and a half years. The vitamins had no effect on overall rates of cardiovascular disease. (7)
    In the Women’s Antioxidant Cardiovascular Study, vitamin E, vitamin C, and/or beta-carotene had much the same effect as a placebo on myocardial infarction, stroke, coronary revascularization, or cardiovascular death, although there was a modest and significant benefit for vitamin E among women with existing cardiovascular disease. 

    Cancer and Antioxidants

    According to medical researchers, palm tocotrienols can suppress the proliferation of breast cancer cells in human beings. Delta tocotrienols are more effective than other forms of tocotrienols in causing apoptosis, or cell death, in breast cancer cells that are estrogen-nonresponsive and estrogen-responsive. When it comes to cancer prevention, the picture remains inconclusive for some antioxidant supplements. Few trials have gone on long enough to provide an adequate test for cancer. In the long-term Physicians’ Health Study, cancer rates were similar among men taking beta-carotene and among those taking a placebo. Other trials have also largely showed no effect, including HOPE. The trial showed a reduction in cancer risk and all-cause mortality among men taking an antioxidant cocktail but no apparent effect in women, possibly because men tended to have low blood levels of beta-carotene and other vitamins at the beginning of the study. In general, tocotrienols function to enhance anti-cancer properties, and it can control tumor growth in certain types of cancer. 

    Age-related eye disease and Antioxidants

    This is the one bright spot for antioxidant vitamins. The Age-Related Eye Disease Study (AREDS), found that a combination of vitamin C, vitamin E, beta-carotene, and zinc offered some protection against the development of advanced age-related macular degeneration, but not cataract, in people who were at high risk of the disease. Lutein, a naturally occurring carotenoid found in green, leafy vegetables such as spinach and kale, may also protect vision. However, relatively short trials of lutein supplementation for age-related macular degeneration have yielded conflicting findings. A new trial of the AREDS supplement regimen plus lutein, zeaxanthin, and fish oil is underway. This trial could yield more definitive information about antioxidants and macular degeneration. 

    Cholesterol reduction

    Antioxidants inhibit cholesterol production in the liver, thereby lowering total blood cholesterol. Alpha tocotreinol suppresses hepatic HMG-CoA reductase activity that results in the lowering of LDL cholesterol levels. Tocotreinols which are naturally occurring in palm oil, have been shown to suppress plasma cholesterol in humans. 

    Reverses Carotid Atherosclerosis

    It has been proven that tocotrienols are effective in reversing carotid atherosclerosis, or arterial blockage, which can help prevent cardiovascular conditions. In a recent study, a number of people who were suffering from carotid atherosclerosis were given 240 mg of palm tocotrienol complex every day for 18 to 36 months. The results showed that cholesterol plaque in the patients’ carotid arteries was significantly reduced. Such effect was not seen in subjects who were given a placebo. Palm based tocotrienol complex protects the ApoE knockout mice against cholesterol build-up and hence prevent arteriosclerosis. Reverses arterial blockage (carotid atherosclerosis), hence reducing the risk factors for cardio-vascular diseases such as atherosclerosis and stroke. 

    Other Health Benefits

    Besides the abovementioned benefits, tocotrienols can also promote health in other ways. They can reduce platelet aggregation, which is a process that can lead to blood clotting. Blood clotting is a serious condition that can result in a number of health problems, which include heart illnesses, neurological disorders, bowel problems, weakness or paralysis of limbs and others. Also, palm-based gamma tocotrienols have the ability to inhibit the development of hypertension. 

    Safety


    • Since tocotrienols are derived from vitamin E, there are no known side effects.

    • Generally, there are no differences in dosage among children and adults, though children under the age of 10 are advised not to use tocotrienols at all unless under the recommendation of a physician.

    • One myth regarding tocotrienols is the idea that their benefits are noticeable even when consumed in natural foods. Some literature even tout the health benefits of consuming a teaspoon of palm oil a day. This is not the case. The amount of tocotrienols found in natural foods like palm oil, barley, wheat, or grain, is so low that there are no appreciable benefits in consuming these foods solely for their supplemental value.

    • While palm oil has the highest concentration of tocotrienols, one will have to consume two cups of palm oil a day in order to have any benefits. It is only through extracting tocotrienols from these foods, particularly from palm oil, that they can have their full potential as a health supplement. 

    Selected references


    1. Bjelakovic G, Nikolova D, Simonetti RG, et al. Antioxidant supplements for preventing gastrointestinal cancers. Cochrane Database Syst Rev 2008 Jul 16;(3):CD004183. 

    2. Boshtam M, Rafiei M, Golshadi ID, et al. Long term effects of oral vitamin E supplement in type II diabetic patients. Int J Vitam Nutr Res 2005 Sep;75(5):341-6. 

    3. Fillenbaum GG, Kuchibhatla MN, Hanlon JT, et al. Dementia and Alzheimer's disease in community-dwelling elders taking vitamin C and/or vitamin E. Ann Pharmacother 2005 Dec;39(12):2009-14.

    4. Gao J, Gao X, Li W, et al. Observational studies on the effect of dietary antioxidants on asthma: a meta-analysis. Respirology 2008 Jun;13(4):528-36. 

    5. Gaziano JM, Glynn RJ, Christen WG, et al. Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial. JAMA 2009 Jan 7;301(1):52-62. 

    6. Isaac MG, Quinn R, Tabet N. Vitamin E for Alzheimer's disease and mild cognitive impairment. Cochrane Database Syst Rev 2008 Jul 16;(3):CD002854. 

    7. Karlson EW, Shadick NA, Cook NR, et al. Vitamin E in the primary prevention of rheumatoid arthritis: the Women's Health Study. Arthritis Rheum 2008 Nov 15;59(11):1589-95. 

    8. Lin J, Cook NR, Albert C, et al. Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial. J Natl Cancer Inst 2009 Jan 7;101(1):14-23.

    9. Lee IM, Cook NR, Gaziano JM, et al. Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial. JAMA 2005 Jul 6;294(1):56-65. 

    10.Mayer-Davis EJ, Nichols M, Liese AD, et al. Dietary intake among youth with diabetes: the SEARCH for Diabetes in Youth Study. J Am Diet Assoc 2006 May;106(5):689-97. 

    11.Orrell RW, Lane RJ, Ross M. A systematic review of antioxidant treatment for amyotrophic lateral sclerosis/motor neuron disease. Amyotroph Lateral Scler 2008 Aug;9(4):195-211. 

    12.Sesso HD, Buring JE, Christen WG, et al. Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial. JAMA 2008 Nov 12;300(18):2123-33. 

    13.Walsh PC. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. J Urol 2005 Nov;174(5):1823-4.

    14.Wluka AE, Stuckey S, Brand C, et al. Supplementary vitamin E does not affect the loss of cartilage volume in knee osteoarthritis: a 2 year double blind randomized placebo controlled study. J Rheumatol 2002;29(12):2585-2591. 

    15.You WC, Brown LM, Zhang L, et al. Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions. J Natl Cancer Inst 2006 Jul 19;98(14):974-83. 




    Tab 3

    I)Reversal of myoblast aging by tocotrienol rich fraction posttreatment.


    Source

    Lim JJ1, Wan Ngah WZ1, Mouly V2, Abdul Karim N1. 

    ABSTRACT

    Skeletal muscle satellite cells are heavily involved in the regeneration of skeletal muscle in response to the aging-related deterioration of the skeletal muscle mass, strength, and regenerative capacity, termed as sarcopenia. This study focused on the effect of tocotrienol rich fraction (TRF) on regenerative capacity of myoblasts in stress-induced premature senescence (SIPS). The myoblasts was grouped as young control, SIPS-induced, TRF control, TRF pretreatment, and TRF posttreatment. Optimum dose of TRF, morphological observation, activity of senescence-associated β -galactosidase (SA- β -galactosidase), and cell proliferation were determined. 50 μ g/mL TRF treatment exhibited the highest cell proliferation capacity. SIPS-induced myoblasts exhibit large flattened cells and prominent intermediate filaments (senescent-like morphology). The activity of SA- β -galactosidase was significantly increased, but the proliferation capacity was significantly reduced as compared to young control. The activity of SA- β -galactosidase was significantly reduced and cell proliferation was significantly increased in the posttreatment group whereas there was no significant difference in SA- β -galactosidase activity and proliferation capacity of pretreatment group as compared to SIPS-induced myoblasts. Based on the data, we hypothesized that TRF may reverse the myoblasts aging through replenishing the regenerative capacity of the cells. However, further investigation on the mechanism of TRF in reversing the myoblast aging is needed. 

    II) Vitamin E tocotrienol supplementation improves lipid profiles in chronic


    Source

    Daud ZA1, Tubie B2, Sheyman M2, Osia R2, Adams J2, Tubie S2, Khosla P1.

    ABSTRACT

    PURPOSE: 

    Chronic hemodialysis patients experience accelerated atherosclerosis contributed to by dyslipidemia, inflammation, and an impaired antioxidant system. Vitamin E tocotrienols possess anti-inflammatory and antioxidant properties. However, the impact of dietary intervention with Vitamin E tocotrienols is unknown in this population. 

    PATIENTS AND METHODS: 

    A randomized, double-blind, placebo-controlled, parallel trial was conducted in 81 patients undergoing chronic hemodialysis. Subjects were provided daily with capsules containing either vitamin E tocotrienol-rich fraction (TRF) (180 mg tocotrienols, 40 mg tocopherols) or placebo (0.48 mg tocotrienols, 0.88 mg tocopherols). Endpoints included measurements of inflammatory markers (C-reactive protein and interleukin 6), oxidative status (total antioxidant power and malondialdehyde), lipid profiles (plasma total cholesterol, triacylglycerols, and high-density lipoprotein cholesterol), as well as cholesteryl-ester transfer protein activity and apolipoprotein A1. 

    RESULTS: 

    TRF supplementation did not impact any nutritional, inflammatory, or oxidative status biomarkers over time when compared with the baseline within the group (one-way repeated measures analysis of variance) or when compared with the placebo group at a particular time point (independent t-test). However, the TRF supplemented group showed improvement in lipid profiles after 12 and 16 weeks of intervention when compared with placebo at the respective time points. Normalized plasma triacylglycerols (cf baseline) in the TRF group were reduced by 33 mg/dL (P=0.032) and 36 mg/dL (P=0.072) after 12 and 16 weeks of intervention but no significant improvement was seen in the placebo group. Similarly, normalized plasma high-density lipoprotein cholesterol was higher (P<0.05) in the TRF group as compared with placebo at both week 12 and week 16. The changes in the TRF group at week 12 and week 16 were associated with higher plasma apolipoprotein A1 concentration (P<0.02) and lower cholesteryl-ester transfer protein activity (P<0.001).

    CONCLUSION: 

    TRF supplementation improved lipid profiles in this study of maintenance hemodialysis patients. A multi-centered trial is warranted to confirm these observations.

    III)Tocotrienol supplementation in postmenopausal osteoporosis: evidence from a laboratory study.


    Source

    Muhammad N, Luke DA, Shuid AN, Mohamed N, Soelaiman IN. 

    ABSTRACT

    OBJECTIVE: 

    Accelerated bone loss that occurs in postmenopausal women has been linked to oxidative stress and increased free radicals. We propose the use of antioxidants to prevent and reverse postmenopausal osteoporosis. This study aimed to examine the effects of tocotrienol, a vitamin E analog, on bone loss due to estrogen deficiency. Our previous study showed that tocotrienol increased the trabecular bone volume and trabecular number in ovariectomized rats. In the current study, we investigated the effects of tocotrienol supplementation on various biochemical parameters in a postmenopausal osteoporosis rat model.

    MATERIALS AND METHODS:

    A total of 32 female Wistar rats were randomly divided into four groups. The baseline group was sacrificed at the start of the study, and another group was sham operated. The remaining rats were ovariectomized and either given olive oil as a vehicle or treated with tocotrienol at a dose of 60 mg/kg body weight. After four weeks of treatment, blood was withdrawn for the measurement of interleukin-1 (IL1) and interleukin-6 (IL6) (bone resorbing cytokines), serum osteocalcin (a bone formation marker) and pyridinoline (a bone resorption marker). 

    RESULTS: 

    Tocotrienol supplementation in ovariectomized rats significantly reduced the levels of osteocalcin, IL1 and IL6. However, it did not alter the serum pyridinoline level. 

    CONCLUSION: 

    Tocotrienol prevented osteoporotic bone loss by reducing the high bone turnover rate associated with estrogen deficiency. Therefore, tocotrienol has the potential to be used as an anti-osteoporotic agent in postmenopausal women.







     BIOGÉNIQUE ADVANTAGES


    Customers who bought this item also bought: