(0)Items in cart View Checkout


About UsContactFAQ

BiotinTM

For Healthy Hair, Skin & Nails

$47.47


100 Tablets     250mcg Biotin

  • Metabolizes carbs, fats and proteins to produce energy*
  • Helps to maintain body’s normal blood glucose levels*
  • Strengthens Hair & Nails*
  • Tab 1

     

    • Essential vitamin for maintaining healthy skin, hair and nails
    • Helps to maintain body’s normal blood glucose levels
    • Metabolizes carbohydrates, fats and proteins to produce energy
    • Important for normal embryonic growth, vital nutrient during pregnancy
    • Prevention and treatment of Biotin deficiency 

    Biotin is part of the B-complex group of vitamins. As these vitamins are water-soluble, it is difficult for the body to store them, therefore they should be replenished daily for optimal health with food or supplements. Obtaining these nutrients from diet alone can be difficult since they are depleted by food processing, storing and cooking. Biogenique B-iotin helps to overcome this loss. 

    Why Biogenique?


    The application of Structurally Active-Orthogenic (SAO) technology by Biogenique’s research and production team ensures that all available products are of a heightened quality. 

    SAO technology produces active ingredients with strong molecular composition and the highest bioavailability (ratio of inactive/active ingredients) in order to ensure synergistic applications occur within the body. In other words, the Biogenique label ensures that all our products are able to be optimally absorbed by the bloodstream at the molecular level, and don’t just pass through the body undigested. 

    Biogenique is pharmaceutically tested and clinically verified by careful examination at every stage of production. The protocols are measured and confirmed for international standard compliance before the product is introduced to market. 

    Biogenique only uses 100% natural ingredients. 




    Tab 1

    Active Ingredients


    Biotin……………………………………………………………………………..250mcg

     

    Tab 3

    BiotinTM

     

    NPN:

     

    80043414

     

    Quantity:


    100 Tablets

     

     

    Non Medicinal Ingredients:

     

    Vegetable croscarmellose sodium, vegetable cellulose-microcrystalline, vegetable silicon dioxide, vegetable magnesium stearate.

     

    This Product Does Not Contain:


    Gelatin, gluten, sugar, dairy or preservatives. 

    Recommended Use:


    A factory in the maintenance of good health. Helps the body to metabolize carbohydrates, fats and proteins and to prevent biotin deficiency. 

    Recommended Dose:


    Adults and adolescents (14 years and over): Take 1-2 capsule(s) daily. 

    Risk Information:

     

    Cautions & Warnings:


    Keep out of reach of children. 

    Storage:


    • Seal for tamper resistant protection.
    • If Seal is broken do not use.
    • Store at room temperature 15-30 C
    • Protect from Moisture 

    download monograph

     

     





    Tab 3

    Tab 3 Content

    Tab 1

    Biogenique Structurally Active-Orthogenic (SAO) technology


    Biotin is a water-soluble vitamin that is generally classified as a B-complex vitamin. All B vitamins help the body to convert food (carbohydrates) into fuel (glucose), which is used to produce energy. These B vitamins, often referred to as B complex vitamins, also help the body metabolize fats and protein. Biogenique SAO technology formulates Biotin of premium quality to replenish the body’s daily requirement. The active ingredient is derived from natural sources and undergoes special process of extraction without heating or storing to prevent essential nutrients from getting destroyed. This active form of Biotin in Biogenique Biotin is readily absorbed by the intestines and catalyzes important metabolic reactions in your body. 

    SAO Analysis


    Biotin functions - Enzyme co-factor
    It catalyzes the binding of bicarbonate to acetyl-CoA to form malonyl-CoA. Malonyl-CoA is required for the synthesis of fatty acids. It is a critical enzyme in gluconeogenesis—the formation of glucose from sources other than carbohydrates. It also catalyzes an essential step in the catabolism of leucine, an essential amino acid. 

    Histone biotinylation
    The attachment of biotin to another molecule, such as a protein, is known as "biotinylation." Histones are proteins that bind to DNA and package it into compact structures to form nucleosomes—integral structural components of chromosomes. Mounting evidence indicates that biotinylation of histones plays a role in regulating DNA replication and transcription as well as cellular proliferation and other cellular responses. 

    Scientific Evidence


    Hair and Nail Problems

    Very weak evidence suggests that biotin supplements may improve thin, splitting, or brittle toe and fingernails, as well as hair. Biotin, combined with zinc and topical clobetasol propionate, has also been used to combat alopecia areata in both children and adults. 

    Cradle Cap (Seborrheic Dermatitis)

    Infants who don't have enough biotin often develop this scaly scalp condition. However, no studies have shown that biotin supplements -- given in formula or breast milk -- effectively treat cradle cap. Always ask your doctor before taking any vitamin, herb, or supplement if you are breastfeeding. 

    Diabetes

    In one study, blood biotin levels were significantly lower in 43 patients with non-insulin dependent diabetes mellitus (NIDDM; type 2 diabetes) than in non-diabetic control subjects, and lower fasting blood glucose levels were associated with higher blood biotin levels. After one month of biotin supplementation, fasting blood glucose levels decreased by an average of 45%. Preliminary research indicates that a combination of biotin and chromium might improve blood sugar control in some people with type 2 diabetes, but biotin alone doesn't seem to have the same effect. More research is needed to know for sure whether biotin has any benefit. 

    Peripheral Neuropathy

    There have been reports that biotin supplements improve the symptoms of peripheral neuropathy for some people who developed this condition from either diabetes or ongoing dialysis for kidney failure. Peripheral neuropathy is nerve damage in the feet, hands, legs, or arms. Numbness, tingling, burning or strange sensations, pain, muscle weakness, and trouble walking are some symptoms. However, there aren’t any studies that evaluate whether biotin really helps treat peripheral neuropathy. 

    Birth defects

    Research indicates that biotin is broken down more rapidly during pregnancy and that biotin nutritional status declines during the course of pregnancy. One study reported that biotin excretion dropped below the normal range during late pregnancy in six out of 13 women, suggesting that their biotin status was abnormally low. A study of 26 pregnant women found that biotin supplementation decreased the excretion of this metabolite compared to placebo, suggesting that marginal biotin deficiency may be relatively common in pregnancy. Although the level of biotin depletion is not severe enough to cause diagnostic signs or symptoms, such observations are sources of concern because subclinical biotin deficiency has been shown to cause birth defects in humans. On balance, the potential risk for teratogenesis (abnormal development of the embryo or fetus) from biotin deficiency makes it prudent to ensure adequate biotin intake throughout pregnancy. Since pregnant women are advised to consume supplemental folic acid prior to and during pregnancy to prevent neural tube defects, it would be easy to consume supplemental biotin in the form of a multivitamin. 

    Safety


    • Biotin is LIKELY SAFE for most people when taken appropriately and by mouth. Biotin is well tolerated when used at recommended dosages.

    • Pregnancy and breast-feeding: Biotin is POSSIBLY SAFE when used in recommended amounts during pregnancy and breast-feeding.

    • That said, biotin has not been associated with side effects, even in high doses, and is considered to be non-toxic.

    • Kidney dialysis: People receiving kidney dialysis may need extra biotin. Check with your health care provider.

    • Older adults (65 years and older): Presently, there is no indication that older adults have an increased requirement for biotin. If dietary biotin intake is not sufficient, a daily multivitamin-mineral supplement will generally provide an intake of at least 30 mcg of biotin/day. 

    Selected references


    1. Baez-Saldana A, Zendejas-Ruiz I, Revilla-Monsalve C, et al. Effects of biotin on pyruvate carboxylase, acetyl-CoA carboxylase, propionyl-CoA carboxylase, and markers for glucose and lipid homeostasis in type 2 diabetic patients and nondiabetic subjects. Am J Clin Nutr. 2004;79:238-43.

    2. Fiume MZ, Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of biotin. Int J Toxicol. 2001;20 Suppl 4:1-12.

    3. Gulati S, Passi GR, Kumar A, Kabra M, Kalra V, Verma IC. Biotinidase deficiency -- a treatable entity. Indian J Pediatr. 2000;67(6):464-466.

    4. Head KA. Peripheral neuropathy: pathogenic mechanisms and alternative therapies. Altern Med Rev. 2006 Dec;11(4):294-329. Review.

    5. Singer GM, Geohas J. The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trial. Diabetes Technol Ther. 2006 Dec;8(6):636-43.

    6. Taniguchi A, Watanabe T. Roles of biotin in growing ovarian follicles and embryonic development in domestic fowl. J Nutr Sci Vitaminol. 2007;53(6):457-63.

    7. National Academy of Sciences. Dietary Reference Intakes (DRIs): Recommended Intakes for Individuals, Vitamins. Accessed June 1, 2011.

    8. McCarthy MF. Toward practical prevention of type 2 diabetes. Med Hypotheses. 2000;54(5):786-793.

    9. Said HM. Biotin: the forgotten vitamin. [editorial] Am J Clin Nutr. 2002;75(2)179-180.

    10. Mock DM, Quirk JG, Mock NI. Marginal biotin deficiency during normal pregnancy. Am J Clin Nutr. 2002;75(2):295-299. 




    Tab 3

    I) The discovery of niacin, biotin, and pantothenic acid.


    Source

    Veterans Affairs Medical Center, Great Lakes VA Healthcare System, Tomah, WI 54660, USA. Douglas.Lanska @ va.gov 

    ABSTRACT

    The aim was to describe the discovery of niacin, biotin, and pantothenic acid. By the 1920s, it became apparent that 'water-soluble B' (vitamin B) is not a single substance. In particular, fresh yeast could prevent both beriberi and pellagra, but the 'antipolyneuritis factor' in yeast is thermolabile, while the antipellagra factor is heat stable, suggesting that there are at least two water-soluble vitamins. Various terms were proposed for these water-soluble factors, but vitamins B(1) and B(2) were most widely used to refer to the thermolabile and heat-stable factors, respectively. Although vitamin B(1) proved to be a single chemical substance (thiamin), vitamin B(2) was ultimately found to be a complex of several chemically unrelated heat-stable factors, including niacin, biotin, and pantothenic acid. Recognition that niacin is a vitamin in the early 20th century resulted from efforts to understand and treat a widespread human disease - pellagra. American epidemiologist and US Public Health Service officer Joseph Goldberger (1874-1929) had been instrumental to elucidating the nutritional basis for pellagra. Goldberger conducted a classic series of observational and experimental studies in humans, combined with an extensive series of experiments with an animal model of the condition (black tongue in dogs). In contrast, recognition that biotin and pantothenic acid are vitamins occurred somewhat later as a result of efforts to understand microbial growth factors. The metabolic roles in humans of these latter substances were ultimately elucidated by human experiments using particular toxins and by studies of rare inborn errors of metabolism. Symptomatic nutritional deficiencies of biotin and pantothenic acid were, and continue to be, rare. 

    II)Temporal development of genetic and metabolic effects of biotin deprivation. A search for the optimum time to study a vitamin deficiency.


    Source

    Unidad de Genética de la Nutrición, Instituto de Investigaciones Biomédicas de la Universidad Nacional Autónoma de México and Instituto Nacional de Pediatría, México City, México. 

    ABSTRACT

    Biotin deficiency (Bt-D) is usually studied at the point at which the animal model exhibits the signs of full-blown deficiency symptoms; in rats, this typically occurs at 6-8 weeks of feeding a deficient diet. To differentiate specific deficiency effects from those of undernutrition, biotin sufficient and deficient rats were studied at 2, 3, 4, and 5 weeks on the deficiency diet, before the onset of weight loss and deficiency signs. The deficiency state was confirmed by biochemical and molecular analyses. Blood and liver metabolites were determined and western blots of signaling proteins, and qRT-PCR gene expression studies. The main effects of Bt-D were already well established by the fourth week on the diet; thus, we consider the fourth week as the optimum time to study the consequences of biotin depletion. Early effects, which were already apparent at week 2, included cellular energy deficit (as assessed by increased AMP/ATP ratio), activation of the AMPK energy sensor, and changes of carbon metabolism gene transcripts (e.g., phosphoenolpyruvate carboxykinase, carnitine palmitoyl transferase 1, liver glucokinase and fatty acid synthetase). Reduced post-prandial blood concentrations of glucose were also observed early; we speculate that these are attributable to augmented sensitivity to insulin and increased glucose utilization, a likely effect of AMPK induction of translocation of glucose transporter GLUT4 to the cell membranes and increased hexokinase expression. Other late-onset changes (week 4) included increased serum concentrations of lactate and free fatty acids and decreased liver glycogen and serum concentrations of triglycerides and total cholesterol. The identification of the early specific molecular and metabolic disturbances of biotin deficiency might be useful in identifying individuals with marginal deficiency of this vitamin, which appears to be common in normal human pregnancy. The study of time-course of other vitamin deficiencies, such as this one, might help to better understand and cope with their effects. 

    III)Biotin deficiency causes spontaneous cell death and activation of defense signaling.


    Source

    Division of Genetics, Department of Biosciences, Viikki Biocenter, University of Helsinki, 00014 Helsinki, Finland. 

    ABSTRACT

    In addition to its essential metabolic functions, biotin has been suggested to play a critical role in regulating gene expression. The first committed enzyme in biotin biosynthesis in Arabidopsis, 7-keto-8-aminopelargonic acid synthase, is encoded by At5g04620 (BIO4). We isolated a T-DNA insertion mutant of BIO4 (bio4-1) with a spontaneous cell death phenotype, which was rescued both by exogenous biotin and genetic complementation. The bio4-1 plants exhibited massive accumulation of hydrogen peroxide and constitutive up-regulation of a number of genes that are diagnostic for defense and reactive oxygen species signaling. The cell-death phenotype was independent of salicylic acid and jasmonate signaling. Interestingly, the observed increase in defense gene expression was not accompanied by enhanced resistance to bacterial pathogens, which may be explained by uncoupling of defense gene transcription from accumulation of the corresponding protein. Characterization of biotinylated protein profiles showed a substantial reduction of both chloroplastic biotinylated proteins and a nuclear biotinylated polypeptide in the mutant. Our results suggest that biotin deficiency results in light-dependent spontaneous cell death and modulates defense gene expression. The isolation and molecular characterization of the bio4-1 mutant provides a valuable tool for elucidating new functions of biotin. 

    IV) Biotin requirements for DNA damage prevention.


    Source

    Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, 316 Ruth Leverton Hall, Lincoln, NE 68583-0806, USA. jzempleni2@unl.edu 

    ABSTRACT

    Abstract Biotin serves as a covalently bound coenzyme in five human carboxylases; biotin is also attached to histones H2A, H3, and H4, although the abundance of biotinylated histones is low. Biotinylation of both carboxylases and histones is catalyzed by holocarboxylase synthetase. Human biotin requirements are unknown. Recommendations for adequate intake of biotin are based on the typical intake of biotin in an apparently healthy population, which is only a crude estimate of the true intake due to analytical problems. Importantly, intake recommendations do not take into account possible effects of biotin deficiency on impairing genome stability. Recent studies suggest that biotin deficiency causes de-repression of long terminal repeats, thereby causing genome instability. While it was originally proposed that these effects are caused by loss of biotinylated histones, more recent evidence suggests a more immediate role of holocarboxylase synthetase in forming multiprotein complexes in chromatin that are important for gene repression. Holocarboxylase synthetase appears to interact physically with the methyl-CpG-binding domain protein 2 and, perhaps, histone methyl transferases, thereby creating epigenetic synergies between biotinylation and methylation events. These observations might offer a mechanistic explanation for some of the birth defects seen in biotin-deficient animal models. 







     BIOGÉNIQUE ADVANTAGES


    Customers who bought this item also bought: